Discover Your Career at Emory University

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Description

The Hansen Lab studies the interactions between satellite cells and the vasculature. Satellite cells are skeletal muscle progenitor cells that are known to play an important role in muscle repair after injury and adaptation to exercise. However, our lab focuses on a previously underexplored role of satellite cells in vascular growth. We have found that satellite cells, when activated, produce a number of chemoattractant growth factors that drive the migration of vascular smooth muscle and endothelial cells which are important in the growth and development of blood vessels. This area is of particular interest in the context of peripheral artery disease (PAD), where patients suffer from ischemic tissue damage but treatment options are still limited. The lab has shown that ischemia stimulates satellite cells and is exploring ways to harness their angiogenic properties in vivo or through therapeutically delivered cells.

Current work in the lab is determining the effects of satellite cell growth factor production using in vitro assays as well as determining what factors are critical to these vascular effects. One major project explores the biology of satellite cells in response to exercise. We are utilizing a mouse model in which we can selectively ablate satellite cells. Additionally, we are exploring the changes in expression and heterogeneity of satellite cells after exercise in both our murine models and human patient biopsies using single cell sequencing. Our newest project is to optimize satellite cell delivery and further develop therapeutic strategies through new biomaterials.

This position would assist the staff scientist and graduate students in the lab with performing a number of in vitro and in vivo experiments. Experience in histology, immunohistochemistry, cell culture, PCR, and Western blotting is preferred.

JOB DESCRIPTION: Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career. The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc. Designs and evaluates experiments. Develops new ideas that promote current research. Prepares and publishes scientific manuscripts under the direction of the Principal Investigator. May be responsible for operation of specific equipment. May teach techniques to others, train, and supervise research staff. Positions are temporary appointments as a research trainee. The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available. Appointments cannot exceed five years. MINIMUM QUALIFICATIONS: A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field. Excellent scientific writing ability and strong oral communication skills. The ability to work effectively and collegially with colleagues. Additional qualifications as specified by the Principal Investigator.

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