Description

The Brugmann Lab is looking for a postdoctoral fellow interested in combining developmental and computational biology to further our understanding of craniofacial development and disease.

Craniofacial abnormalities (CFAs) are associated with approximately one-third of all birth defects. Patients with a CFA represent a biomedical burden nearly 45 times higher than unaffected children; and in the U.S. alone, the lifetime cost for treating children born with CFAs is approximately $697 million per year. The Brugmann laboratory focuses on understanding the molecular, cellular, and genetic factors that guide craniofacial development. To do so, we have focused on the function of the primary cilium, a ubiquitous, microtubule-based organelle used by all cells to integrate and transduce molecular signals. We aim to elucidate how primary cilia function during facial development and uncover how basic cellular processes are impacted when cilia are impaired. To achieve this goal, we generate and analyze large data sets (RNA-seq, ChIP-seq, CUT&RUN) from animal (murine and avian) and human (iPSC) ciliopathic models.

Relevant publications: eLife 2020 PMID: 33006313

MAJOR DUTIES AND RESPONSIBILITIES:

Design, execute, and record laboratory experiments, and analyze the data.

Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.

Present research at laboratory meetings, journal clubs, seminars, and meetings.

Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.

Maintain currency in field through continuing education, literature, and seminars.

Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures.

Perform other duties as assigned.

Cincinnati Children's Research and Training at a Glance

• Among the top in NIH funding for pediatric research institutions
• Over 1.4 million square feet of research laboratory space
• 900+ scientists conducting basic, translational, and clinical research
• Over 2000 publications annually in top-tier journals
• Access to Employee Resource Groups and Mentorship programs
• Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.

Learn more about the Postdoctoral Fellowship Program.

Compensation and Benefits

• Postdoctoral Research Fellows and Associates are eligible for:
  • Group Health, Dental, and Vision Insurance Plans
  • Paid Time Off
  • Retirement Plan
  • Tuition Reimbursement
  • Relocation Benefits for Eligible Hires

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Qualifications

EDUCATION\WORK EXPERIENCE: Ph.D. in related discipline, MD, or equivalent required.

Interested candidates must have a PhD and have a strong record of accomplishments and experience in:
1- Developmental biology, Molecular biology, Craniofacial biology, Ciliary biology; OR
2- Bioinformatics, computational biology.

We are looking for a colleague who is highly motivated and independent.

REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.

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About Cincinnati Children's Hospital Medical Center

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.

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