Description

Expected Starting Salary: - Salaries align with NIH Exramural scale for postdocs

The Chen lab (www.zychenlab.org) is looking for a postdoctoral fellow for a fully funded position studying epigenetic mechanisms in development.

Research Directions
We are interested in how epigenomic landscape is established during oogenesis and early development and how the epigenetic memories are maintained or reprogrammed during parental-to-zygotic transition. Some of Dr. Chen's past work has explored oocyte H3K27me3-dependent non-canonical genomic imprinting (Chen et al., 2019 Science Advances, Chen et al, 2020 Nature Review Genetics), Polycomb landscape in early development (Chen et al., 2021 Nature Genetics), and mechanism of zygotic genome activation (Chen et al., 2019 Nature Genetics).

Approaches
We take a multi-disciplinary approach with a heavy focus on functional genomics. We routinely generate novel genetically modified mouse models for studying oogenesis and embryonic development. We are good at numerous epigenomic profiling technologies that can work with rare biological materials such as mouse oocytes and pre-implantation embryos. If needed, we invent new techniques to address interesting questions in developmental biology. In addition to in vivo models, we also use embryonic stem cells for genome-wide screening experiments and some mechanistic studies because they mimic early embryos to some extent and can be genetically engineered within a short period of time.

MAJOR DUTIES AND RESPONSIBILITIES:

Design, execute, and record laboratory experiments, and analyze the data.

Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.

Present research at laboratory meetings, journal clubs, seminars, and meetings.

Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.

Maintain currency in field through continuing education, literature, and seminars.

Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures.

Perform other duties as assigned.

Cincinnati Children's Research and Training at a Glance

• Among the top in NIH funding for pediatric research institutions
• Over 1.4 million square feet of research laboratory space
• 900+ scientists conducting basic, translational, and clinical research
• Over 2000 publications annually in top-tier journals
• Access to Employee Resource Groups and Mentorship programs
• Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.

Learn more about the Postdoctoral Fellowship Program.

Compensation and Benefits

• Postdoctoral Research Fellows and Associates are eligible for:
  • Group Health, Dental, and Vision Insurance Plans
  • Paid Time Off
  • Retirement Plan
  • Tuition Reimbursement
  • Relocation Benefits for Eligible Hires

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Living in Cincinnati

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Qualifications

EDUCATION/EXPERIENCE

REQUIRED

Ph.D. in related discipline, MD, or equivalent required.

We believe you will be an excellent fit if you:

Have a Ph.D degree in reproductive sciences, developmental biology, epigenomics, or related fields. Prior experience in bioinformatics is preferred but not required.

Have strong communication skills and high self-motivation.

Unique Skills:

Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.

Cincinnati Children's is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families (EEO/AA).

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About Cincinnati Children's Hospital Medical Center

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.

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