A postdoctoral position is available immediately in the Department of Neurosciences, University of California San Diego; Dr. Paula Desplats’ laboratory
The Desplats lab is interested in understanding epigenetic deregulation that may contribute to adult neurodegenerative disorders. We apply a variety of models ranging from human postmortem brain samples; transgenic mouse models and primary cell lines to understand disease changes and to decipher mechanisms of gene regulation. Our lab has a long-standing trajectory on unraveling disease mechanisms associated with alpha-synuclein missfolding and accumulation (PNAS 2009, 106(31): 13010-5; JBC 2012 287(38): 31691-702), including pioneering epigenetic analysis in Parkinson’s disease (Epigenetics2013, 8(10): 1030). The candidate postdoc will have the opportunity to work primarily in a new exciting project studying the relation between alterations on dynamic DNA methylation and disruption of circadian rhythms and Alzheimer’s disease pathology, extending our recent studies (Alzheimer’s Dement. 2017, 13(6):689-700). The postdoctoral researcher will also have the chance to collaborate in other ongoing projects related Parkinson’s disease, and is expected to contribute to train undergraduate students rotating in the lab.
We are looking for a self-motivated individual with strong creative and critical thinking; detail-oriented and goal-driven researcher who is an exceptional team player.
PhD. in neurosciences, molecular or cell biology.
Expertise in molecular biology and transcription analysis.
Previous work on neurodegeneration; circadian biology or epigenetics.
Experience on -omics analysis packages is highly desirable.
Experience with mouse models of neurodegeneration is preferred.
Advanced skills in tissue culture, including primary cell cultures.
A record of high-impact peer-reviewed publications is highly desirable.
Very good written and oral communication skills.
If you are interested in joining a growing and vibrant lab with a passion for translational science and to enjoy the highly collaborative neuroscience community of San Diego please contact the PI at firstname.lastname@example.org including c.v. and a brief description of researcher interests.
Internal Number: 022019
About University of California San Diego
Research in our lab is aimed at elucidating the dynamic mechanisms of DNA methylation, which might contribute to onset and progression of the most prevalent neurodegenerative diseases of the elderly, Parkinson’s and Alzheimer’s. At the center of our work is a strong interest in translational neuroscience, therefore we combine aspects of cellular physiology and molecular neuroscience, integrating the analysis of human postmortem brain samples, transgenic animals and cellular models to address mechanistic questions, while identifying therapeutic targets and providing novel diagnostic tools.